Description

Doxycycline is a bacteriostatic agent that acts by interfering with the bacterial protein synthesis of sensitive species.

Doxycycline is a semi-synthetic tetracycline derived from oxytetracycline. It acts on the subunit 30S of the bacterial ribosome, to which it is linked reversibly, blocking the union between aminoacyl-tRNA (transfer RNA) to the mRNA-ribosome complex, preventing the addition of new aminoacids into the growing peptide chain and thus

interfering with protein synthesis.

Doxycycline is active against Gram-positive and Gram-negative bacteria.

Spectrum of activity:

Streptococcus spp.

Staphylococcus aureus

Chlamydia spp.

Mycoplasma spp.

Salmonella spp.

Pasteurella multocida

Bordetella bronchiseptica

Indications

Chickens (broilers):

Prevention and treatment of chronic respiratory disease (CRD) and mycoplasmosis caused by microorganisms sensitive to doxycycline.

Pigs:

Prevention of clinical respiratory disease due to Pasteurella multocida and Mycoplasma hyopneumoniae sensitive to doxycycline.

The presence of the disease in the herd should be established before treatment.

Contra indications

Do not use in case of hypersensitivity to tetracyclines.

Do not use in animals with hepatic dysfunction.

Do not administer to laying birds four weeks before the start of lay and during lay.

Do not use during pregnancy or lactation.

Side effects

Allergic and photosensitivity reactions can occur. Intestinal flora may be affected if treatment is very prolonged, and this may result in digestive disturbance.

Dosage

For oral administration. Chickens (broilers): 11.5 – 23 mg doxycycline hyclate / kg body weight / day, corresponding to 0.1 – 0.2 ml Doxysol Oral per kg body weight, for 3-5 consecutive days. Pigs: 11.5 mg doxycycline hyclate/ kg body weight / day, corresponding to 0.1 ml of Doxysol Oral per kg body weight, for 5 consecutive days.

Withdrawal times

- For meat & offal:

Chickens (broilers) : 7 days

Pigs : 7 days

- Eggs: Not permitted for use in laying birds producing eggs for human consumption.

Packaging

Bottle of 1000 ml.