Description

Albendazole is a synthetic anthelmintic which belongs to the group of benzimidazole-derivatives with activity against a broad range of worms and at a higher dosage level also against adult stages of liver fluke.

Pharmacological Action

Albendazole combined with eelworm's microtubule protein and play a role. After albenzene combined with β- tubulin, it can prevent dimerization between albenzene and α  tubulin assembling into microtubules. Microtubules are the basic structure of the many cell units. Albendazole's affinity to nematodes tubulin is significantly higher than the affinity of mammalian tubulin, so toxicity to mammalian is small.

Indications

Prophylaxis and treatment of worminfections in calves and cattle like:

Gastrointestinal worms: Bunostomum, Cooperia, Chabertia, Haemonchus, Nematodirus,Oesophagostomum, Ostertagia, Strongyloides and Trichostrongylus spp.

Lung worms: Dictyocaulus viviparus and D. filaria.

Tapeworms: Monieza spp.

Liver-fluke: adult Fasciola hepatica.

Albendazole has also an ovicidal effect.

Contra-Indications

Administration in the first 45 days of gestation.

Side Effects

Hypersensitivity reactions.

Dosage

For oral administration.

For roundworms ,tapeworms:

Cattle / buffalo / horse / sheep / goat: 5mg/kg bodyweight

Dog / cat: 10 to 25mg/kg bodyweight

For flukes:

Cattle/buffalo: 10mg/kg bodyweight

Sheep/goat: 7.5mg/kg bodyweight

Calves and cattle: 1 bolus per 300 kg. body weight.

For liver-fluke:

1 bolus per 250 kg. body weight.

Withdrawal Times

- For meat : 12 days.

- For milk : 4 days.

Storage

Store in tightly cool, dry place protected from light.